MD, MSc, PhD, MRCP(UK), CCST(UK)
Professor of Pediatrics – Pediatric and Adolescent Endocrinology
National and Kapodistrian University of Athens Medical School
First Department of Pediatrics, ‘Aghia Sophia’ Children’s Hospital
Evangelia Charmandari graduated from the University of Thessaloniki Medical School, as a valedictorian of her class (highest distinction). She completed her specialization in Pediatrics in the UK and she was awarded the ‘Membership of Royal College of Physicians [MRCP(UK)]’. She was further subspecialized in Pediatric and Adolescent Endocrinology at the London Centre for Paediatric Endocrinology and Metabolism, at Great Ormond Street Hospital for Children and University College Hospital, London, UK. She was awarded the ‘Certificate of Completion of Specialist Training in General Pediatrics (CCST-General Pediatrics)’, and ‘Certificate of Completion of Specialist Training in Pediatric Endocrinology’ (CCST-Pediatric Endocrinology) by the Royal College of Pediatrics and Child Health, London, UK.
She obtained a Master of Science in Clinical Pediatrics and a PhD in Pediatric and Adolescent Endocrinology, which were awarded by the University College London, University of London, in 1998 and 2001, respectively. She subsequently undertook a Postdoctoral fellowship in Molecular Endocrinology and Cellular Biology at the National Institute of Child Health and Human Development (NICHD), National Institutes of Health (NIH), Bethesda, MD, USA (2000-2004). She also worked as a Consultant in Pediatric and Adolescent Endocrinology at St. James’ University Hospital and Leeds General Infirmary, Leeds, UK (2006-2007).
Following 15 years of clinical and research (clinical, translational and basic science) work in the UK and USA, Dr. Charmandari returned back to Greece in 2007 having been awarded a European Union reintegration grant. She used this opportunity to establish and develop the Laboratory of the Division of Endocrinology and Metabolism, Center for Clinical, Experimental Surgery and Translational Research at the Biomedical Research Foundation of the Academy of Athens (BRFAA) (2007-2010).
In February 2011, Dr. Charmandari joined the faculty of the National and Kapodistrian University of Athens Medical School as an Associate Professor, and became Full Professor of Pediatric and Adolescent Endocrinology in 2015. She carries out her clinical and research work at the Division of Endocrinology, Metabolism and Diabetes, First Department of Pediatrics, “Aghia Sophia” Children’s Hospital in Athens, Greece. She is also the scientific supervisor of the Division of Endocrinology and Metabolism, Center for Clinical, Experimental Surgery and Translational Research at the Biomedical Research Foundation of the Academy of Athens (BRFAA).
Her research work led to 344 publications in refereed peer-review journals (108 in SCI journals, 9 in non-SCI journals, 1 book, 56 chapters in books and 170 publications in conference proceedings). Her publications have an impact factor of 665.918, personal impact factor of 567.318 and received 6789 Google Scholar citations (H index = 41, i10 index = 77) and 4336 Scopus citations (H index = 36).
She received the ‘Henning Andersen Prize’ of the European Society for Pediatric Endocrinology, as well as several awards by the Hellenic Endocrine Society, the Hellenic Society for Adolescent Medicine, the Medical Association of Athens and the Health Business Awards. Finally, she received research funding of €1,680,000.00 as Principal Investigator (PI) and €790,000 Ευρώ as Co-PI from the European Union and Greece.
A complete list of her publications is available in the PubMed, her ResearcherID is B-6701-2011, her ORCID is 0000-0002-0851-6998, her Scopus Author ID is 7004635158, while her Google scholar profile is here.
Henning Andersen Prize, European Society for Pediatric Endocrinology, June 2007
Prize for Best Research Proposal in Pediatric Endocrinology, Hellenic Endocrine Society, 2010
Prize for Best Research Proposal in Pediatric Endocrinology, Hellenic Endocrine Society, 2012
‘Farmakioti’ Prize for best Poster Presentation, Hellenic Endocrine Society, 2013
Prize for Best Basic Science Research in Endocrinology, Hellenic Endocrine Society, 2016
‘Ikkou’ Prize for Best Clinical Research in Endocrinology, Hellenic Endocrine Society, 2016
e-Health Award – Electronic applications for a comprehensive care of patients, Health Care Business Awards, 2016
Prize for Best Basic Science Research in Endocrinology, Hellenic Endocrine Society, 2017
‘Georgios Maragkos’ Prize, Hellenic Society for Adolescent Medicine, 2019
Bangalore Krishna K, Fuqua JS, Rogol AD, Klein KO, Popovic J, Houk CP, Charmandari E, Lee PA. Use of Gonadotropin-Releasing Hormone Analogs in Children: Update by an International Consortium. Hormone Research in Paediatrics 2019; 18:1-16.
Kassari P, Papaioannou P, Billiris A, Karanikas H, Eleftheriou S, Thireos E, Manios Y, Chrousos GP, Charmandari E. Electronic Registry for the Management of Childhood Obesity in Greece. European Journal of Clinical Investigation 2018; 48(3). doi: 10.1111/eci.12887.
Kyritsi EM, Koltsida G, Farakla I, Papanikolaou A, Critselis E, Mantzou E, Zoumakis E, Kolaitis G, Chrousos GP, Charmandari E. Psychological vulnerability to stress in carriers of congenital adrenal hyperplasia due to 21-hydroxylase deficiency. Hormones (Athens). 2017; 16(1):42-53.
Charmandari E, Nicolaides N, Chrousos GP. Adrenal Insufficiency. Lancet 2014; 383(9935): 2152-67.
Roberts ML, Kino T, Nicolaides NC, Hurt DE, Katsantoni E, Sertedaki A, Komianou F, Kassiou K, Chrousos GP, Charmandari E. A Novel Point Mutation in the DNA-Binding Domain (DBD) of the Human Glucocorticoid Receptor Causes Primary Generalized Glucocorticoid Resistance by Disrupting the Hydrophobic Structure of its DBD. Journal of Clinical Endocrinology & Metabolism 2013; 98(4): E790-5.
Charmandari E., Achermann JC, Carel JC, Soder O, Chrousos GP. Stress response and child health. Science Signaling 2012; 5(248): mr1.
Charmandari E. Primary generalized glucocorticoid resistance and hypersensitivity: the end-organ involvement in the stress response. Science Signaling 2012; 5(244): pt5.
Charmandari E., Sertedaki A, Kino T, Merakou C, Hoffman DA, Hatch MM, Hurt DE, Lin L, Xekouki P, Stratakis CA, Chrousos GP. A Novel Point Mutation in the KCNJ5 Gene Causing Primary Hyperaldosteronism and Early-Onset Autosomal Dominant Hypertension. Journal of Clinical Endocrinology & Metabolism 2012; 97(8): E1532-9.
Charmandari E., Chrousos GP, Lambrou GI, Pavlaki A, Koide H, Ng SSM, Kino T. Peripheral CLOCK regulates target-tissue glucocorticoid receptor transcriptional activity in a circadian fashion in man. PLoS One 2011; 6(9): e25612.
Nicolaides N, Galata Z, Chrousos GP, Charmandari E.The glucocorticoid receptor: Evolution, structure and molecular basis of biologic function. Steroids 2010; 75(1): 1-12.
Kino T, Ichijo T, Zachman K, Chrousos GP, Charmandari E. A novel point mutation in the amino terminal domain of the human glucocorticoid receptor (hGR) gene enhancing hGR-mediated gene expression. Journal of Clinical Endocrinology & Metabolism 2008; 93(12): 4963-8.
Charmandari E., Kino T, Ichijo T, Chrousos GP. Generalized Glucocorticoid Resistance: Clinical Aspects, Molecular Mechanisms and Implications of a Rare Genetic Disorder. Journal of Clinical Endocrinology & Metabolism 2008; 93(5): 1563-72.
Kino T, Souvatzoglou E, Charmandari E., Ichijo T, Driggers P, Mayers C, Alatsatianos A, Manoli I, Westphal H, Chrousos GP, Segars JH. RHO family guanine nucleotide exchange factor BRX couples extracellular signals to the glucocorticoid signaling system. Journal of Biological Chemistry 2006; 281(14): 9118-9126.
Charmandari E., Raji A, Kino T, Ichijo T, Tiulpakov A, Zachman K, Chrousos GP. A novel point mutation in the ligand-binding domain (LBD) of the human glucocorticoid receptor (hGR) causing generalized glucocorticoid resistance: The importance of C-terminus of hGR LBD in conferring transactivational activity. Journal of Clinical Endocrinology & Metabolism 2005; 90(6): 3696-3705.
Charmandari E., Tsigos C, Chrousos GP. Endocrinology of the stress response. Annual Reviews of Physiology 2005; 67: 259-284.
Charmandari E., Chrousos GP, Ichijo T, Bhattacharyya N, Vottero A, Souvatzoglou E, Kino T. The human glucocorticoid receptor (GR) β isoform suppresses the transcriptional activity of GRα by interfering with formation of active coactivator complexes. Molecular Endocrinology 2005; 19(1): 52-64.
Charmandari E., Merke DP, Negro PJ, Keil MF, Martinez PE, Haim A, Gold PW, Chrousos GP. Endocrinologic and psychologic evaluation of 21-hydroxylase deficiency carriers and matched normal subjects: evidence for physical and/or psychologic vulnerability to stress. Journal of Clinical Endocrinology & Metabolism 2004; 89(5): 2228-2236.
Charmandari E., Eisenhofer G, Mehlinger SL, Carlson A, Wesley R, Keil MF, Chrousos GP, New MI, Merke DP. Adrenomedullary function may predict phenotype and genotype in classic 21-hydroxylase deficiency. Journal of Clinical Endocrinology & Metabolism 2002; 87(7): 3031-3037.
Charmandari E., Weise M, Bornstein SR, Eisenhofer G, Keil MF, Chrousos GP, Merke DP. Children with classic congenital adrenal hyperplasia have elevated serum leptin concentrations and insulin resistance: Potential clinical implications. Journal of Clinical Endocrinology & Metabolism 2002; 87(5): 2114-2120.
Charmandari E., Hindmarsh PC, Johnston A, Brook CGD. Alterations in cortisol pharmacokinetics at puberty. Journal of Clinical Endocrinology & Metabolism 2001; 86(6): 2701-2708.
Charmandari E., Johnston A, Brook CGD, Hindmarsh PC. Bioavailability of oral hydrocortisone in patients with congenital adrenal hyperplasia. Journal of Endocrinology 2001; 169(1): 65-70.
Charmandari E., Brook CGD. 20 years of experience in idiopathic central diabetes insipidus. Lancet 1999; 353 (9171): 2212-2213.