Stress activates the central and peripheral components of the stress system, i.e., the hypothalamic-pituitaryadrenal (HPA) axis and the arousal/sympathetic system. Appropriate responsiveness of the stress system to stressors is a crucial prerequisite for a sense of well-being, adequate performance of tasks and positive social interactions. By contrast, inappropriate responsiveness of the stress system may impair growth and development, and may account for a number of endocrine, metabolic, autoimmune and psychiatric disorders. The development and severity of these conditions primarily depend on the genetic vulnerability of the individual, the exposure to adverse environmental factors and the timing of the stressful event(s), given that prenatal life, infancy, childhood and adolescence are critical periods characterized by increased vulnerability to stressors.
Publications
11. Emmanouil CC, Pervanidou P, Charmandari E, Darviri C, Chrousos GP. The effectiveness of a health promotion and stress-management intervention program in a sample of obese children and adolescents. Hormones (Athens). 2018; 17(3): 405-413.
10. Stefa A, Lamprokostopoulou A, Briana D, Kontogeorgou A, Papageorgiou I, Malamitsi-Puchner A, Tsitsilonis O, Gagos S, Charmandari E. The effect of intrauterine growth on leukocyte telomere length at birth. Journal of Maternal-Fetal & Neonatal Medicine 2018; 6: 1-6.
9. Vardas K, Ilia S, Sertedaki A, Charmandari E, Briassouli E, Goukos D, Apostolou K, Psarra K, Botoula E, Tsagarakis S, Magira E, Routsi C, Stratakis CA, Nanas S, Briassoulis G. Increased glucocorticoid receptor expression in sepsis is related to heat shock proteins, cytokines, and cortisol and is associated with increased mortality. Intensive Care Medicine Experimental 2017; 5(1): 10.
8. Nicolaides NC, Charmandari E, Kino T, Chrousos GP. Stress-related and circadian secretion and target tissue actions of glucocorticoids: Impact on health. Frontiers in Endocrinology (Lausanne). 2017; 8:70.
7. Stavrou S, Nicolaides NC, Critselis E, Darviri C, Charmandari E, Chrousos GP. Paediatric stress: from neuroendocrinology to contemporary disorders. European Journal of Clinical Investigation 2017; 47(3): 262-269.
6. Markou A, Sertedaki A, Kaltsas G, Androulakis I, Marakaki C, Pappa T, Gouli A, Papanastasiou L, Fountoulakis S, Zacharoulis A, Karavidas A, Ragkou D, Charmandari E, Chrousos GP, Piaditis GP. Stress-induced aldosterone hypersecretion in a substantial subset of patients with essential hypertension. Journal of Clinical Endocrinology & Metabolism 2015; 100(8): 2857-64.
5.Nicolaides N, Kyratzi E, Lamprokostopoulou A, Chrousos G, Charmandari E. Stress, stress system and the role of glucocorticoids. Neuroimmunomodulation 2015; 22(1-2): 6-19.
4. Charmandari E, Achermann JC, Carel JC, Soder O, Chrousos GP. Stress response and child health. Science Signaling 2012; 5(248): mr1.
3.Chrousos GP, Kino T, Charmandari E. Evaluation of the hypothalamic-pituitary-adrenal axis function in childhood and adolescence. Neuroimmunomodulation 2009; 16(5): 272-283.
2. Charmandari E, Tsigos C, Chrousos GP. Endocrinology of the stress response. Annual Reviews of Physiology 2005; 67: 259-284.
1. Charmandari E, Kino T, Souvatzoglou E, Chrousos GP. Pediatric stress: Hormonal mediators and stress response. Hormone Research 2003; 59(4): 161-179.